Anti-Ms TCR Gamma/Delta, GL3, FI, 200µg

A laboratory reagent from STEMCELL Technologies, this monoclonal antibody, Clone GL3, targets the δ chain of the murine T cell receptor γ/δ (TCR gamma/delta), a disulfide-linked γ/δ heterodimer of approximately 80 kDa in humans that associates with CD3 on the cell surface and belongs to the immunoglobulin superfamily [S3]. TCRγ/δ participates in recognizing both peptide and lipid antigens [S2, S3]. GL3 reportedly recognizes an epitope in the constant region of the δ chain and can reportedly activate TCRγ/δ+ cells [S3]. The antibody is of hamster host origin with an IgG2, kappa isotype [S3].

TCRγ/δ is expressed on a subpopulation of T cells in the circulation but may be found on up to 50% of T cells in epithelial cell-rich tissues, where they have roles in oral and tumor-associated tolerance as well as autoimmune disease, and have been described as a link between the adaptive and innate immune responses [S3]. Most γ/δ T cells are CD4-/CD8-, although some express CD8 [S3].

This FITC-conjugated format is supplied as a clear liquid and is intended for use as a laboratory reagent [S1]. It has been demonstrated by flow cytometry analysis of C57BL/6 mouse lymph node cells labeled with the GL3 antibody, FITC together with Anti-Mouse CD3e Antibody, Clone 145-2C11, APC [S2]. According to the manufacturer's safety data sheet, the product is not classified as a hazardous substance or mixture according to the Globally Harmonized System (GHS) [S1].