Anti-Ms EPCR, RMEPCR1560, 100µg

STEMCELL Technologies offers a monoclonal antibody (Clone RMEPCR1560) raised in rat against mouse endothelial protein C receptor (EPCR), also known as CD201. The target is an ~25 kDa type I transmembrane glycoprotein expressed by endothelial cells, subsets of hematopoietic stem cells (HSCs) and dendritic cells, and several malignant cell lines; it is also found in a soluble form in plasma. EPCR exhibits homology with the MHC class 1/CD1 protein family and binds Protein C and activated Protein C, augmenting Protein C activation by the thrombin-thrombomodulin complex and regulating blood coagulation and inflammation.

EPCR protein expression has been detected on ~1.5% of mouse bone marrow cells. Purified EPCR+ cells are highly enriched for HSC activity, as evidenced by high in vivo repopulation activity, making EPCR useful as a single marker for the identification of mouse HSCs. The antibody is suitable for cell isolation, flow cytometry (FC), and Western blot (WB). Available conjugation options include biotin, FITC, PE, and unconjugated formats. The isotype is IgG2b, kappa.

According to the manufacturer's Safety Data Sheet, the reagent is supplied as a clear liquid and is not classified as a hazardous substance or mixture according to the Globally Harmonized System (GHS) or the 2012 OSHA Hazard Communication Standard. It is intended as a laboratory reagent for research use only, supplied by STEMCELL Technologies Canada Inc. in Vancouver, British Columbia. Recommended storage is to keep containers tightly closed in a dry, cool, and well-ventilated place. The product is not regulated for transport under DOT, TDG, MEX, ICAO, IATA, IMDG, RID, or ADR.