Anti-Ms CD62L, MEL-14, FI, 100µg

This FITC-conjugated monoclonal antibody from STEMCELL Technologies, clone MEL-14, targets murine CD62L (also known as L-Selectin or LECAM-1), a type I glycoprotein of approximately 74 - 95 kDa expressed on the surface of a majority of leukocytes. CD62L mediates leukocyte–endothelial cell interactions through association with ligands including CD34, glyCAM-1, MAdCAM-1 and PSGL-1, facilitating lymphocyte rolling on the vascular endothelium, lymphocyte trafficking to lymph nodes, and homing of lymphocytes and neutrophils to sites of inflammation.

Murine CD62L is expressed on most thymocytes, with the highest expression on subsets of immunocompetent or dividing progenitor cells, as well as on neutrophils, eosinophils, monocytes and subsets of B, T and NK cells. The antibody may be used in combination with other surface-marker antibodies to distinguish naïve, memory and effector T cells, and has been shown to block migration of lymphocytes to lymph nodes and to inhibit leukocyte rolling. The reagent is a rat IgG2a, kappa antibody intended for flow cytometry, and the liquid preparation has a clear appearance with a green hue. According to the manufacturer's Safety Data Sheet, the product is not classified as a hazardous substance or mixture under the Globally Harmonized System (GHS).