Anti-Ms CD49b, DX5, AZ, 100µg

This anti-mouse CD49b antibody, supplied by STEMCELL Technologies, is the rat IgM, kappa DX5 clone provided in APC-conjugated format. CD49b (integrin α2) is an approximately 150 kDa type 1 transmembrane glycoprotein that associates non-covalently with CD29 (integrin β1) to form the heterodimeric VLA-2 complex, a receptor for extracellular matrix proteins such as collagen, E-cadherin, fibronectin and laminin. The antibody is suitable for flow cytometry and cell separation, with applications in cell isolation, flow cytometry, and immunohistochemistry.

CD49b is highly expressed by platelets and is found on a majority of NK cells, on NKT cells, and on a small subset of CD8+ T cells, the latter population increasing substantially following viral infection. The antigen is also expressed by several tissues, including intestine, kidney, mammary gland and lung. The DX5 clone is particularly useful for identifying NK cells in mice lacking the NK1.1 antigen. Binding of the DX5 antibody has not been observed to affect the function of the VLA-2 integrin, although DX5 binding is blocked by the clone HMα2 antibody.

According to the manufacturer's safety data sheet, the product is a clear liquid and is not classified as a hazardous substance or mixture.