Anti-Ms CD44, IM7, AD, 100µg

STEMCELL Technologies offers a rat monoclonal antibody that recognizes CD44 (Ly-24), an approximately 80 - 95 kDa type 1 transmembrane glycoprotein involved in cell-cell and cell-matrix interactions. Clone IM7 reacts with an extracellular epitope found on all isoforms of CD44 and both murine allotypes, and is of the IgG2b, kappa isotype.

CD44 is expressed on the surface of many cell types, including leukocytes, hepatocytes, endothelial, epithelial, and mesenchymal cells; expression levels increase upon activation of T and B cells, with memory cells exhibiting a CD44[High] phenotype. The antibody binds ligands such as hyaluronic acid, collagen, fibronectin, growth factors, and metalloproteinases, modulating processes including lymphocyte activation, recirculation and homing, leukocyte rolling and aggregation, hematopoiesis, and tumor metastasis.

The clone has been verified for purity assessments of cells isolated with EasySep kits, including the EasySep Mouse CD4+ T Cell Enrichment Kit, and is used in cell isolation, ELISA, and flow cytometry applications. Reactive species include baboon, cat, chimpanzee, cow, cynomolgus monkey, dog, horse, human, mouse, pig, rhesus monkey, and squirrel monkey.