Anti-Ms CD4 , RM4-5, PE, 50µg

STEMCELL Technologies offers this PE-conjugated rat antibody (clone RM4-5, isotype IgG2a, kappa) directed against mouse CD4, a ~55 kDa single-chain type 1 transmembrane glycoprotein and member of the immunoglobulin superfamily. CD4 contains four extracellular Ig-like domains and is expressed at relatively high levels by most thymocytes and a subpopulation of T cells (T-helper/inducer cells), and at lower levels on dendritic cells; in the mouse it is not expressed by monocytes/macrophages. The antibody binds CD4 and inhibits ligand binding in vitro, and its binding can be blocked by the clone GK1.5 antibody. CD4 normally engages a non-polymorphic region of MHC II, acting as a co-receptor to the T cell receptor to enhance avidity of the TCR–MHC II–antigen interaction.

The reagent is supplied as a clear liquid and is intended for research use only, not for human or animal diagnostic or therapeutic applications unless otherwise stated. It has been verified for purity assessments of cells isolated with EasySep kits, including the EasySep Mouse CD4+ T Cell Enrichment Kit and the EasySep Mouse CD4+ T Cell Isolation Kit. The product is not classified as hazardous under the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200) and is not regulated for transport by DOT, TDG, ICAO, IATA, IMDG, RID, ADR, or ADN.