Anti-Ms CD24, M1/69, AZ, 100µg

STEMCELL Technologies offers this rat antibody, Clone M1/69, which reacts with murine CD24, an approximately 35 - 45 kDa glycoprotein expressed on lymphocytes, granulocytes, thymocytes, erythrocytes, epithelial cells, neurons, and dendritic cells.

CD24 is differentially expressed during T and B cell development and is not found on the majority of mature peripheral T cells or plasma cells. It is expressed on pro-B, pre-B, and mature B cells, but expression is strongly down-regulated after B cell activation. CD24 is involved in regulating B-cell apoptosis and in preventing terminal differentiation of B cells into antibody-secreting plasmablasts and plasma cells. It acts as an adhesion or co-stimulatory molecule and is involved in lymphocyte activation, proliferation, and differentiation through homophilic interactions or by binding to ligands such as P-selectin (CD62P).

This primary antibody (isotype IgG2b, kappa) is offered in unconjugated form as well as conjugated to Alexa Fluor 488, APC, biotin, FITC, PE, or PerCP-Cyanine5.5. Recommended applications include CyTOF, flow cytometry, functional assays, immunocytochemistry, immunofluorescence, immunohistochemistry, and Western blot. The antibody supports research areas such as epithelial cell biology and immunology, including the culture and evaluation of mouse mammary epithelial cells and the immunomagnetic negative isolation of untouched mouse B cells. The associated Gene ID is 12484.