Anti-Ms CD138, 281-2, BT, 500µg

This biotin-conjugated monoclonal antibody from STEMCELL Technologies (Clone 281-2) targets an extracellular epitope on the core protein of mouse CD138 (Syndecan-1), described as a ~60 - 100 kDa type 1 transmembrane glycoprotein. CD138 is expressed on pre-B cells, immature B cells, and normal and malignant plasma cells, but not on mature circulating B cells, and is also found on non-hematopoietic cells including embryonic mesenchymal, endothelial, epithelial, and neural cells. The molecule is thought to act as a receptor that modulates cell proliferation, cell migration, and cell-matrix associations by linking the extracellular matrix to the cytoskeleton, with its heparin sulfate and chondroitin sulfate moieties associating with proteins such as collagens, fibronectin, tenascin, thrombospondin, and certain cytokines.

The Clone 281-2 antibody has been verified for flow cytometry. It is a rat IgG2a, kappa reagent intended for research applications including cell separation, flow cytometry, functional assays, immunocytochemistry, immunofluorescence, immunohistochemistry, immunoprecipitation, and Western blot, supporting work in cancer research and immunology. The same clone is also offered by STEMCELL Technologies in APC, PE, and unconjugated formats.