Anti-Ms CD11c, N418, AD, 25µg

Manufactured by STEMCELL Technologies, this Anti-Mouse CD11c Antibody, Clone N418 is a hamster (Armenian) monoclonal IgG antibody that reacts with mouse CD11c (αX integrin), a 150 kDa type 1 transmembrane glycoprotein. CD11c associates non-covalently with CD18 (β2 integrin) to form a heterodimeric cell surface adhesion receptor. Through interaction with ligands such as iC3b, fibrinogen and CD54, the receptor is involved in immune response processes including cell migration, stimulation of cytokine production by monocytes and macrophages, T cell proliferation, leukocyte recruitment, and phagocytosis. In mice, CD11c is expressed on dendritic cells, macrophages, monocytes, granulocytes, NK cells, and a subset of T cells.

Verified applications include cell separation (CellSep) and flow cytometry (FC), and reported applications include CyTOF®, flow cytometry, immunocytochemistry (ICC), immunofluorescence (IF), immunohistochemistry (IHC), and immunoprecipitation (IP). The antibody is conjugated to Alexa Fluor® 488 and is supplied as a phosphate-buffered solution at pH 7.2 containing 0.09% sodium azide. It has been purified by affinity chromatography.

For storage, the product is stable at 2 - 8°C when stored undiluted; freezing should be avoided. The product is intended for research use only.