Anti-Hu CD19, HIB19, PS, 100tests

This antibody reagent from STEMCELL Technologies targets the human CD19 antigen and is supplied as a clear liquid laboratory reagent. The Clone HIB19 antibody recognizes CD19, an approximately 95 kDa type 1 transmembrane glycoprotein expressed on the surface of B cells throughout all stages of development, from early pre-B cells to plasma cells. Expression is down-regulated but persists in terminally differentiated plasma cells, and CD19 is also found on follicular dendritic cells.

By associating with CD21 and CD81, CD19 functions as a co-receptor for the B cell receptor and is involved in B cell activation and differentiation. Activation of CD19 is accompanied by phosphorylation of the cytoplasmic domain, which promotes binding to kinases and the induction of intracellular signaling cascades. Mutations in CD19 can result in severe immunodeficiency syndromes.

This format is conjugated to PerCP-Cy5.5 and is suitable for applications such as cell isolation and flow cytometry. The clone has been verified for purity assessments of cells isolated with EasySep™ kits. The reagent is intended for research use only and is not for human or animal diagnostic or therapeutic uses unless otherwise stated. Per the manufacturer's safety data sheet, the product is classified as not hazardous under GHS and is chemically stable under normal conditions.