Anti-Hu CD19, HIB19, AD, 100tests

This mouse monoclonal IgG1, kappa antibody from STEMCELL Technologies, designated Anti-Human CD19, Clone HIB19, reacts with CD19, an approximately 95 kDa type 1 transmembrane glycoprotein expressed on the surface of B cells throughout all stages of development, from early pre-B cells to plasma cells. Expression is down-regulated but persists in terminally differentiated plasma cells, and CD19 is also found on follicular dendritic cells.

By associating with CD21 and CD81, CD19 functions as a co-receptor for the B cell receptor and is involved in B cell activation and differentiation. Activation of CD19 is accompanied by phosphorylation of the cytoplasmic domain, which promotes binding to kinases and the induction of intracellular signaling cascades. Mutations in CD19 can result in severe immunodeficiency syndromes.

The antibody is reactive with chimpanzee and human cells and is suitable for applications including cell separation, CyTOF, flow cytometry, functional assays, and immunohistochemistry. It is available in multiple conjugation formats, including Alexa Fluor 488, APC, biotin, FITC, PE, PerCP-Cyanine5.5, and unconjugated, and has been verified for purity assessments of cells isolated with EasySep™ kits. The associated gene is listed with Gene ID 930.