Anti-Hu CD14, M5E2, AZ, 100t

From STEMCELL Technologies, this Anti-Human CD14 Antibody (Clone M5E2) is an APC-conjugated mouse monoclonal IgG2a antibody that reacts with human, rhesus, and cynomolgus CD14. The antibody is designed for flow cytometry applications and is intended for research use only, not for human or animal diagnostic or therapeutic uses unless otherwise stated.

CD14 is an approximately 53 - 55 kDa GPI-anchored transmembrane glycoprotein expressed at high levels on peripheral blood monocytes and macrophages, and at lower levels on granulocytes. An approximately 10-fold difference in expression levels between monocytes/macrophages and granulocytes makes CD14 a useful marker for distinguishing these cell populations. CD14 is also found on tissue macrophages, Langerhans cells, and dendritic cells. The antibody targets a protein that functions as a high-affinity receptor for complexes of lipopolysaccharide (LPS) and serum LPS-binding protein, modulating LPS-dependent signal transduction during the immune response.

The product is supplied as a clear liquid. According to the manufacturer's safety data sheet, the chemical is not considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200) and is stable under normal conditions. It should be stored with containers kept tightly closed in a dry, cool, and well-ventilated place.