Anti-Hu CD11b, ICRF44, AD, 25tests

A mouse monoclonal IgG1, kappa antibody from STEMCELL Technologies, Clone ICRF44, targets human CD11b (integrin αM), an approximately 170 kDa type 1 transmembrane glycoprotein that associates non-covalently with CD18 to form the heterodimeric Mac-1 receptor. The clone has been verified for flow cytometry and is supplied as a clear liquid that is not classified as hazardous according to the Globally Harmonized System (GHS).

Through its interactions with ligands such as ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, heparin and fibrinogen, Mac-1 influences several processes including the adherence of neutrophils and monocytes to stimulated endothelium and the phagocytosis of complement-coated particles. CD11b is expressed on the surface of granulocytes, monocytes, NK cells, dendritic cells, tissue macrophages and subsets of T and B cells, and has been used as a marker to distinguish naïve and memory CD8+ T cells. The ICRF44 antibody reportedly inhibits leukocyte aggregation in response to the chemoattractant fMLP.

Products from STEMCELL Technologies are intended for research use only and are not intended for human or animal diagnostic or therapeutic uses unless otherwise stated. The company's quality management system is certified to ISO 13485. This antibody clone has also been verified for labeling human mesenchymal cells grown in MesenCult™ Proliferation Kit (Human) and MesenCult™-XF Medium.