TREM2 Signaling Pathways ELISA Sampler Kit

The TREM2 Signaling Pathways ELISA Sampler Kit from Assay Genie consolidates five complementary 48-assay microplate panels into a single reagent box, allowing laboratories to map multiple downstream mediators of Triggering Receptor Expressed on Myeloid cells 2 (TREM2) activation without sourcing individual kits. TREM2 is a single-pass transmembrane immunoglobulin receptor that signals through the DAP12/TYROBP adaptor and is widely investigated in microglial biology, neuroinflammation, and Alzheimer's disease research.

For research use only, each component panel quantifies a distinct analyte relevant to TREM2-coupled cascades such as phagocytic clearance, cell survival signaling, and cytokine release in human myeloid model systems. The kit is supplied as a complete pack containing pre-coated microplate strips, lyophilized standards, biotinylated detection antibodies, and assay buffers sufficient for the 5x 48 assays configuration.

For sample handling, frozen aliquots of liquid specimens or cell culture supernatant should be thawed on ice and applied at a sample volume of 50 uL per well, with standard curves run in duplicate across the supplied microplate strips. Reagents not in use are stored refrigerated at 4 degrees C and protected from light to preserve antibody binding activity, while unused strips are returned to the foil pouch with desiccant. Standard curve range, sensitivity, and species reactivity information are detailed in the lot-specific certificate of analysis supplied with each Assay Genie sampler.