Rat Presenilin 2 (PS2) ELISA Kit

Presenilin 2 is a multi-pass transmembrane aspartyl protease that forms the catalytic core of the gamma-secretase complex, an intramembrane protease responsible for cleaving amyloid precursor protein and other type I transmembrane substrates. Genetic variants of the PSEN2 gene cause early-onset familial Alzheimer's disease, so quantitative measurement of PS2 levels supports research into neurodegenerative mechanisms, amyloidogenic processing, and gamma-secretase regulation.

This rat-reactive ELISA kit from Assay Genie is configured for in vitro quantification of endogenous Presenilin 2 in tissue homogenates and cell lysates from rat model systems. The kit is intended for research use only and accommodates standard laboratory workflows, supporting parallel analysis of experimental samples and reference standards across a single microplate. Researchers studying APP processing, familial Alzheimer's disease, presenilin biology, or comparative neurobiology in rodent models can incorporate this assay to monitor PS2 expression under different genetic, pharmacological, or environmental conditions.

Assay Genie provides the reagents and pre-coated microplate needed to perform the immunoassay, and full procedural detail is supplied with the kit documentation. Sample preparation from dissected rat brain regions and peripheral tissues is straightforward, and the procedure is compatible with standard spectrophotometric plate readers commonly found in research laboratories.