Rat Neurogenic locus notch homolog protein 1 (Notch1) ELISA Kit

A Sandwich ELISA Kit from Assay Genie designed for the quantitative detection of Neurogenic locus notch homolog protein 1 (Notch1) in rat samples. The kit is intended for research use only and supports investigations into neurogenesis, cell differentiation, and cell fate determination. NOTCH1 signaling has been linked to diseases including cancer, cardiovascular disorders, and neurodevelopmental conditions, making this assay a useful tool for researchers exploring these biological pathways and potential therapeutic targets.

Acceptable sample types include serum and plasma, with reactivity confirmed for rat. NOTCH1 functions as a receptor for the membrane-bound ligands Jagged1, Jagged2 and Delta1. Following ligand activation, the protein undergoes proteolytic processing and the notch intracellular domain (NICD) is translocated to the nucleus, where it forms a transcriptional activator complex that regulates genes involved in differentiation, proliferation, and apoptotic programs.