Rat Mothers against decapentaplegic homolog 3 (Smad3) ELISA Kit

Quantitative measurement of Mothers against decapentaplegic homolog 3 (SMAD3) in rat biological samples is supported by this Sandwich ELISA from Assay Genie, which delivers high sensitivity and specificity for research applications targeting the TGF-beta pathway.

SMAD3 is a key intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases, regulating cell growth, differentiation and apoptosis. Dysregulation of SMAD3 has been linked to fibrosis, cancer and inflammatory disorders, highlighting its importance as a potential therapeutic target and biomarker in studies of disease pathogenesis, drug development and biomarker discovery.

The kit is validated for serum, plasma, tissue homogenates, cell culture supernates and other biological fluids, with a detection range of 0.312-20ng/mL and a sensitivity of 0.196ng/mL. Specificity covers natural and recombinant rat SMAD3 (UniProt P84025), and the product is intended for research within the cancer area.