Rat Kelch Like ECH Associated Protein 1 (KEAP1) ELISA Kit

KEAP1 is a 624-amino-acid cysteine-rich protein that sequesters the Nrf2 transcription factor under homeostatic conditions, targeting it for proteasomal degradation via the Cul3-RBX1 E3 ubiquitin ligase complex. Upon oxidative or electrophilic stress, reactive cysteines on KEAP1 are modified, releasing Nrf2 to activate antioxidant response element (ARE)-driven transcription of phase II detoxification and cytoprotective genes.

Quantitative measurement of KEAP1 levels with this Assay Genie kit supports research into Nrf2 pathway dysregulation in hepatotoxicity, neuroinflammation, pulmonary injury, fibrosis, and carcinogenesis. Store reagents refrigerated at 4 degrees C; aliquot the reconstituted standard and limit freeze-thaw cycles to preserve calibration integrity. For research use only, in vitro applications.