Rat Janus Kinase 3 (JAK3) ELISA Kit

Quantitative measurement of Janus Kinase 3 in rat samples is supported by this Assay Genie JAK3 ELISA Kit, configured for tissue homogenates and cell lysates. JAK3 is a non-receptor tyrosine kinase expressed predominantly in lymphoid cells, where it transduces signals from common gamma-chain cytokine receptors such as IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Loss-of-function mutations in JAK3 are linked to autosomal recessive severe combined immunodeficiency (SCID), making accurate protein quantification valuable for studies of T-cell and NK-cell development, transplant tolerance, and autoimmune disease models.

Researchers investigating signal transduction, kinase pathway mapping, and pharmacological screening for JAK inhibitors can use the assay to compare endogenous JAK3 protein levels across treated and untreated cohorts. Each kit supplies reagents sufficient for 96 determinations, with an absorbance-based endpoint readout compatible with standard microplate readers in most research laboratories.

The kit is intended for research use only and should be handled as a refrigerated reagent upon arrival, with components stored according to the supplied manual to preserve antibody binding activity across the workflow.