Rat Dihydropyrimidine Dehydrogenase (DPYD) ELISA Kit

Quantitative measurement of dihydropyrimidine dehydrogenase in rat-derived samples is supported by this Assay Genie ELISA Kit, advancing research into pyrimidine catabolism and fluoropyrimidine drug metabolism. DPYD catalyzes the rate-limiting step in uracil and thymine degradation, making this enzyme a critical target in pharmacogenomic and toxicological studies, particularly those examining 5-fluorouracil sensitivity and chemotherapy-induced toxicity.

This colorimetric assay accommodates multiple sample matrices from rat models, including rat serum samples, plasma specimens, tissue homogenate preparations, and other relevant specimen types for laboratory analysis. Researchers in oncology, pharmacology, and metabolic disease use this kit to investigate enzyme activity, gene polymorphism effects, and drug response phenotypes in rodent models of human disease. The 96-assay kit format provides sufficient throughput for cohort studies and dose-response investigations in translational research.

The kit supports investigations into hepatic function, drug-induced liver injury, and inherited metabolic disorders, where altered DPYD activity contributes to pathological states. Studies using this ELISA format commonly explore regulatory mechanisms of pyrimidine metabolism and identify biomarkers for treatment stratification in preclinical workflows involving in vitro and tissue-based analysis.