Rat Amyloid Beta Peptide 1-40 (Ab1-40) ELISA Kit

The Rat Amyloid Beta Peptide 1-40 (Ab1-40) ELISA Kit from Assay Genie is a competitive inhibition immunoassay specifically developed for quantifying the 40-residue amyloid-beta cleavage product of amyloid precursor protein (APP) in rat samples. This shorter Aβ isoform is abundantly secreted under physiological conditions and serves as a critical biomarker in Alzheimer's disease research, particularly when paired with measurements of the more aggregation-prone Aβ1-42 peptide to assess disease-relevant Aβ42/Aβ40 ratios.

The assay employs a competitive binding format in which sample-derived Aβ1-40 competes with coated peptide for binding to a specific antibody, with detection achieved through an enzymatic color change. Researchers working with rodent models of neurodegeneration, transgenic APP-expressing rats, or cerebrospinal fluid profiling studies rely on this kit for longitudinal monitoring of cerebral amyloidosis, drug efficacy testing in candidate therapeutics, and characterization of amyloidogenic pathways in experimental cohorts.

The assay shows no significant cross-reactivity with rat Aβ1-42, enabling selective quantification of the 1-40 isoform. For laboratory handling, store the kit at 4°C and protect it from light; reconstituted reagents should be aliquoted and frozen to limit freeze-thaw cycles, supporting consistent performance across experimental replicates.