Rat Alpha-1-antiproteinase (Serpina1) ELISA Kit

Assay Genie provides a Sandwich ELISA Kit designed for the quantitative detection of rat Alpha-1-antiproteinase (Serpina1). The assay is reactive with rat samples and is intended for research use only. It detects natural and recombinant rat Alpha-1-antiproteinase with a detection range of 1.56-100 ng/ml and a sensitivity of 0.809 ng/mL.

Reported performance characteristics include an intra-assay CV of 6.5% and an inter-assay CV of 9.1%. The kit accepts serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids. Alpha-1-antiproteinase, also known as alpha-1-antitrypsin, alpha-1-proteinase inhibitor, and Serpin A1, is a serine protease inhibitor whose primary target is elastase, with moderate affinity for plasmin and thrombin. The protein is secreted, has a molecular weight of 46,136 Da, corresponds to UniProt accession P17475, and is annotated under NCBI Gene ID 24648.

SERPINA1 has been described as a protease inhibitor playing a role in protecting tissues from proteolytic damage, and its dysregulation has been implicated in conditions such as liver cirrhosis, emphysema, and inflammatory disorders, supporting its use as a biomarker in related research.