p53 (Phospho-Ser392)Transcription Factor Activity Assay

Assay Genie’s colorimetric, solid-phase ELISA kit is designed to assess DNA-binding activity of p53 phosphorylated at Ser-392. The manufacturer lists reactivity with human and mouse samples, nuclear or cell lysates as sample types, an assay time of “4.5 hours,” and colorimetric detection at “450 nm.”

Target annotation describes p53 as a tumor suppressor in many tumor types. It can induce growth arrest or apoptosis depending on physiological circumstances and cell type, and participates in cell-cycle regulation as a trans-activator that negatively regulates cell division.