Mouse Ubiquilin-2 (Ubqln2) ELISA Kit

From Assay Genie, the Mouse Ubiquilin-2 (Ubqln2) ELISA Kit is a sandwich-format immunoassay for the quantitative measurement of UBQLN2 in mouse specimens. The assay accepts serum, plasma, tissue homogenates, cell culture supernates and other biological fluids, and is specific for both natural and recombinant mouse Ubiquilin-2. Detection spans a range of 0.156-10ng/mL with a sensitivity of 0.078ng/mL, and the read-out is by ELISA. The target is associated with neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS) and Alzheimer's disease, and plays a key role in protein degradation and regulation, contributing to the maintenance of cellular homeostasis. It functions through pathways including the ubiquitin-proteasome system, autophagy, and the endoplasmic reticulum-associated protein degradation (ERAD) pathway.

Precision is reported as an intra-assay CV of 5.2% and an inter-assay CV of 7.6%. Linearity has been established across serum (84-120%), EDTA plasma (89-116%) and heparin plasma (85-119%) at serial dilutions, while recovery averages 105% (range 99-111%) in serum and 107% (range 101-113%) in plasma. Synonyms for the target include Chap1, DSK2 homolog, Protein linking IAP with cytoskeleton 2, Ubiquitin-like product Chap1/Dsk2, PLIC-2, and Plic2. The kit is supplied within the Cell Biology research area and is for research use only.