Mouse Tumor necrosis factor ligand superfamily member 11 (Tnfsf11) ELISA Kit

A sandwich ELISA kit from Assay Genie for the quantitative measurement of mouse Tumor necrosis factor ligand superfamily member 11 (Tnfsf11), also known as RANKL. The kit is reactive with mouse samples and is validated for use with serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. It is intended for research use only in the field of immunology.

Performance characteristics include a detection range of 12.5-800pg/mL and a sensitivity of 7.5pg/mL, with an intra-assay CV of 6.4% and an inter-assay CV of 8.9%. The assay specifically detects natural and recombinant mouse Tnfsf11. Spike-and-recovery testing returned average values of 82% (range 80-88%) for serum and 84% (range 80-90%) for plasma samples.

Tnfsf11 is a cytokine that binds TNFRSF11B/OPG and TNFRSF11A/RANK, functioning as an osteoclast differentiation and activation factor involved in bone metabolism and immune regulation, with dysregulation linked to conditions such as osteoporosis and rheumatoid arthritis. The kit is stored at -20°C and shipped at +4°C (international: +4°C).