Mouse Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) ELISA Kit

Mouse TIMP-2 is encoded by the Timp2 gene on chromosome 11 and, unlike other TIMP family members, exhibits dual roles beyond MMP inhibition: it modulates cell cycle progression through the CD63 and integrin signaling axis and is essential for normal ovarian granulosa cell function. Researchers commonly apply this kit to murine models of cardiac remodeling after myocardial infarction, unilateral ureteral obstruction kidney fibrosis, bleomycin-induced pulmonary fibrosis, and excisional wound healing, where TIMP-2 to MMP balance shifts inform collagen turnover and inflammatory resolution.

The Assay Genie kit supports longitudinal sampling from individual animals because only 100 uL of sample is needed per well, and reconstituted standard curves remain stable through six freeze-thaw cycles when aliquoted and held at -80 degrees C. Pairing TIMP-2 readouts with TIMP-1 measurements from matched samples helps distinguish extracellular matrix remodeling from purely inflammation-driven processes in fibrotic and tumor models.