Mouse Tissue factor pathway inhibitor (Tfpi) ELISA Kit

Manufactured by Assay Genie, this Sandwich ELISA is designed for the quantitative measurement of Tissue factor pathway inhibitor (TFPI) in mouse samples, including serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. The assay is specific for natural and recombinant mouse Tissue factor pathway inhibitor and uses a colorimetric detection method.

The kit delivers a detection range of 78-5000pg/mL with a reported sensitivity of 39.4pg/mL. TFPI is described as a key regulator of the coagulation cascade, acting to inhibit the tissue factor pathway and prevent excessive blood clotting. Dysregulation of TFPI has been implicated in various pathological conditions, including thrombosis, sepsis, and cardiovascular diseases, making it a relevant target for therapeutic research.

Target synonyms include Extrinsic pathway inhibitor, Lipoprotein-associated coagulation inhibitor, EPI, LACI and TFPI. The protein is secreted and inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. The associated UniProt entry is O54819. Intra-assay CV, inter-assay CV, linearity and recovery data are provided with the kit. For research use only.