Mouse Suppressor of cytokine signaling 2 (Socs2) ELISA Kit

A sandwich-format colorimetric immunoassay from Assay Genie, this kit enables quantitative detection of mouse Suppressor of cytokine signaling 2 (Socs2) in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids. Intended for research use only, the assay supports immunological studies of cytokine signal transduction and inflammation.

Manufacturer specifications report a detection range of 78-5000 pg/mL and a sensitivity of 39 pg/mL, with an intra-assay CV of 6.2% and an inter-assay CV of 8.7%. Specificity is directed against natural and recombinant mouse SOCS2.

SOCS2 proteins contribute to a classical negative feedback system that regulates cytokine signal transduction, acting as a negative regulator in the growth hormone/IGF1 signaling pathway. They also function as probable substrate recognition components of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins.