Mouse Suppressor of cytokine signaling 1 (Socs1) ELISA Kit

From Assay Genie, this Sandwich ELISA Kit is designed for the quantitative detection of Suppressor of Cytokine Signaling 1 (SOCS1) levels in mouse serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. SOCS1 is a key regulator of cytokine signaling pathways with a critical role in immune response and inflammation, and its dysregulation has been implicated in autoimmune diseases, cancer, and other inflammatory conditions, making it a valuable biomarker for studying these diseases and potential therapeutic interventions.

The assay is configured as a Sandwich ELISA with a detection range of 0.47-30ng/mL and a sensitivity of 0.239ng/mL. Reported performance characteristics include an intra-assay CV of 6.2% and an inter-assay CV of 8.7%. Linearity was evaluated across serial dilutions for serum, EDTA plasma, and heparin plasma samples. Recovery averaged 84% in serum (range 80-90%) and 86% in plasma (range 80-92%). Specificity covers natural and recombinant mouse SOCS1.

Intended for research use only, the kit supports work in the immunology research area. The target is referenced by synonyms including JAK-binding protein, STAT-induced STAT inhibitor 1, JAB, SSI-1, SOCS-1, Cish1, and Ssi1. SOCS1 functions as part of a classical negative feedback system that regulates cytokine signal transduction, notably through the JAK/STAT3 pathway, and is involved in the negative regulation of cytokines that signal through this route, including IL6 and LIF.