Mouse Succinate Dehydrogenase Complex Subunit B (SDHB) ELISA Kit

The Mouse SDHB ELISA Kit from Assay Genie provides quantitative measurement of succinate dehydrogenase iron-sulfur subunit B, a 30 kDa protein that anchors mitochondrial respiratory Complex II to the inner mitochondrial membrane while shuttling electrons from succinate to ubiquinone in the Krebs cycle. Researchers in cancer metabolism use this assay to investigate hereditary paraganglioma-pheochromocytoma syndromes, SDH-deficient renal cell carcinoma, and succinate dehydrogenase-deficient gastrointestinal stromal tumors, where biallelic SDHB loss drives succinate accumulation, HIF-α stabilization, and pseudohypoxic transcriptional reprogramming. The kit is widely applied in mouse models of mitochondrial myopathy, neurodegeneration, and metabolic disorders. Reagents should be stored refrigerated and protected from light; reconstituted standards should be aliquoted and frozen to limit freeze-thaw cycles. Intended for in vitro research use only, this microplate-based kit processes mouse tissue homogenates.