Mouse SPOP (Speckle Type POZ Protein) ELISA Kit (MOES01499)

Quantitative measurement of Speckle Type POZ Protein (SPOP) in mouse research samples is supported by this ELISA kit from Assay Genie, supplied as a 96-assay microplate-format product useful for studies of E3 ubiquitin ligase adaptor biology. SPOP acts as a substrate adaptor within the Cullin 3-based ubiquitin ligase complex, directing ubiquitination of substrates that include androgen receptor, steroid receptor coactivator-3, and several transcriptional regulators. Recurring missense mutations in the SPOP substrate-binding cleft are investigated in prostate cancer and renal cell carcinoma research, where altered target recognition contributes to oncogenic signaling and drug resistance phenotypes. The kit produces a colorimetric readout and is intended for in vitro research use only. Scientists studying tumor suppressor pathways, protein homeostasis, and BTB/POZ domain-mediated protein-protein interactions can use this kit to quantify SPOP levels across mouse model samples derived from cell lysates or clarified tissue homogenates.