Mouse Sperm protamine P1 (Prm1) ELISA Kit

A high-quality Sandwich ELISA from Assay Genie designed for the quantitative detection of Mouse Sperm protamine P1 (Prm1) levels in mouse samples. Also referred to by the synonyms Cysteine-rich protamine and Prm-1, this protein is found in sperm chromatin and plays a critical role in sperm DNA packaging and protection. Abnormalities in protamine P1 levels have been linked to male infertility and subfertility, making this kit a valuable tool for researchers studying reproductive health and fertility issues in mouse models.

The kit is for research use only and is reactive with mouse. It accepts a broad range of sample types, including serum, plasma, tissue homogenates, cell culture supernates and other biological fluids, and is specific for natural and recombinant mouse Sperm protamine P1. The assay delivers a detection range of 0.156-10ng/mL and a sensitivity of 0.051ng/mL.

Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis, compacting sperm DNA into a highly condensed, stable and inactive complex. The protein is cross-linked by interchain disulfide bonds around the DNA-helix and is localised to the nucleus chromosome.