Mouse Serum amyloid P-component (Apcs) ELISA Kit

From Assay Genie, this Mouse Serum Amyloid P-component (Apcs) ELISA Kit is a sandwich-format immunoassay for the quantitative measurement of mouse APCS in biological samples. The assay is reactive against mouse targets and is validated for use with serum, plasma, tissue homogenates, cell culture supernates and other biological fluids, with specificity for both natural and recombinant mouse Serum amyloid P-component. Detection is read colorimetrically.

APCS is a secreted homopentamer of the pentraxin family with a discoid arrangement of five non-covalently bound subunits. According to manufacturer information, the protein can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. It is described as a calcium-dependent lectin and as a precursor of amyloid component P found in basement membrane and associated with amyloid deposits. APCS is noted to play a role in the regulation of inflammation and immune responses, with relevance to amyloidosis and other inflammatory conditions. Listed synonyms are SAP, Ptx2 and Sap, and the research area is given as Neurosciences.

Manufacturer specifications state a detection range of 3.12-200ng/mL and a sensitivity of 1.62ng/mL. The kit is mapped to UniProt entry P12246, and intra-assay CV, inter-assay CV, linearity and recovery are provided with the kit. The product is intended for research use only.