Mouse Renin receptor (Atp6ap2) ELISA Kit

Assay Genie offers a sandwich ELISA for quantitative measurement of mouse Renin receptor (Atp6ap2), with reactivity validated for mouse samples. The kit supports research into the renin-angiotensin system, which regulates blood pressure and fluid balance, and is implicated in cardiovascular and renal disorders.

Using colorimetric detection, the assay reports a standard curve range of 0.156–10 ng/mL and a sensitivity of 0.059 ng/mL. Precision performance is documented with an intra-assay CV of 4.8% and an inter-assay CV of 10.6%. Validated sample types include serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids, and the assay is specific for natural and recombinant mouse Renin receptor.

The target, Atp6ap2 (UniProt Q9CYN9), is a 39,092 Da single-pass type I membrane protein that functions as a renin and prorenin cellular receptor. It may mediate renin-dependent cellular responses by activating ERK1 and ERK2, and may increase the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, contributing to its role in the renin-angiotensin system. Synonyms include ATPase H(+)-transporting lysosomal accessory protein 2, ATPase H(+)-transporting lysosomal-interacting protein 2, Renin/prorenin receptor, and Atp6ip2.