Mouse Receptor-type tyrosine-protein phosphatase alpha (Ptpra) ELISA Kit

From Assay Genie, this Sandwich ELISA Kit is designed for the quantitative measurement of mouse Receptor-type tyrosine-protein phosphatase alpha (PTPRA) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. The assay uses a colorimetric detection method and is intended for research use only. Published target synonyms include LCA-related phosphatase, PTPTY-28, Protein-tyrosine phosphatase alpha, Lrp, and Ptpa.

Reported performance includes a detection range of 0.078–5 ng/mL and a sensitivity of 0.038 ng/mL, with specificity for natural and recombinant mouse PTPRA. The protein is a receptor protein tyrosine phosphatase containing an extracellular domain, a single transmembrane segment, and two tandem intracytoplasmic catalytic domains. It is localised to the membrane as a single-pass type I membrane protein and has been reported to dephosphorylate and activate Src family tyrosine kinases, with implicated roles in integrin signaling, cell adhesion, and proliferation.

Components supplied include an ELISA microplate, lyophilized standard, sample diluent, assay diluents A and B, detection reagents A and B, wash buffer, substrate, stop solution, and plate sealer; storage conditions vary by component as detailed in the kit documentation.