Mouse Ras-related protein Rab-14 (Rab14) ELISA Kit

A Sandwich ELISA Kit designed by Assay Genie for the quantitative detection of mouse Ras-related protein Rab-14 (Rab14) in research samples. Rab14 is a key regulatory protein involved in intracellular vesicle trafficking and membrane dynamics, with roles in endocytosis, exocytosis, and recycling of cell surface receptors. Dysregulation of Rab14 has been implicated in cancer, infectious diseases, and metabolic disorders, making it a valuable biomarker for studying these conditions and potential therapeutic targets.

The kit employs a Sandwich ELISA detection format and is intended for use with serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. It detects natural and recombinant mouse Ras-related protein Rab-14 with a reported detection range of 0.78–50 ng/mL and a sensitivity of 0.18 ng/mL. Reported linearity for serum (N=5) is 91-100% at 1:2, 90-100% at 1:4, 94-104% at 1:8, and 101-110% at 1:16; for EDTA plasma 106-116%, 107-117%, 101-110%, and 106-116%; and for heparin plasma 107-117%, 91-104%, 103-114%, and 96-106%.

Per UniProt, the protein functions together with its guanine nucleotide exchange factor DENND6A in endocytic transport of ADAM10, N-cadherin/CDH2 shedding, and cell-cell adhesion, and is involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development, including regulation of FGFR-containing vesicle transport. It falls within the signal transduction research area and is localized to recycling endosomes, early endosome membrane, Golgi apparatus, trans-Golgi network membrane, and cytoplasmic vesicles, and is recruited to phagosomes containing S. aureus or M. tuberculosis. For research use only.