Mouse PWWP domain-containing protein MUM1 (Mum1) ELISA Kit

This sandwich ELISA kit from Assay Genie is designed for the quantitative detection of mouse PWWP domain-containing protein MUM1 in serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids. The assay uses a colorimetric detection method and is reactive with mouse samples, with a reported detection range of 78-5000pg/mL and a sensitivity of 39.1pg/mL. Specificity is described for natural and recombinant mouse PWWP domain-containing DNA repair factor 3A.

The target protein has a molecular weight of 76,069 Da and is localised to the nucleus, where it is involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. It is recruited to the vicinity of DNA breaks by TP53BP1, interacting with TP53BP1 via its BRCT domain, binding nucleosomes, and interacting with trimethylated 'Lys-36' of histone H3 (H3K36me3) in vitro. Synonyms listed for the protein include Mutated melanoma-associated antigen 1, MUM-1, and PWWP3A. The kit is intended for research use only, within the Cell Biology research area.