Mouse PVRL1 (Poliovirus Receptor Related Protein 1) ELISA Kit (MOES01383)

As a calcium-independent immunoglobulin-like adhesion molecule of the nectin family, poliovirus receptor related protein 1 (PVRL1), also called Nectin-1 and CD111, contributes to adherens junction assembly in epithelial tissues and serves as an entry receptor exploited by herpes simplex virus glycoproteins during host-cell invasion. Assay Genie supplies a colorimetric ELISA configured for quantitative measurement of this target in mouse specimens, presented in a microplate format that supports ninety-six determinations per run and intended for in vitro research use only.

PVRL1 mediates both homophilic trans-interactions with itself and heterophilic binding with other nectin family partners, helping to organize cadherin-based junctional complexes at sites of cell-cell contact. In the nervous system it concentrates at neuronal synapses, while in testis it participates in Sertoli cell–germ cell adhesion, and in ocular and craniofacial epithelia it has been linked to proper tissue morphogenesis. Researchers tracking HSV-1 and HSV-2 entry, neuronal synaptogenesis, or epithelial barrier integrity routinely quantify mouse PVRL1 to follow expression changes across genetic, pharmacological, or disease-model interventions. Reagents should be refrigerated between uses and protected from light to preserve signal stability.