Mouse Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial (Clpp) ELISA Kit

Designed for the accurate quantification of putative ATP-dependent Clp protease proteolytic subunit (CLPP) in mouse samples, this sandwich ELISA is offered by Assay Genie. The kit targets the mitochondrial CLPP protein (synonym: Endopeptidase Clp) and is intended for research use only, with high sensitivity and specificity for reproducible results across a range of research applications.

Validated sample types include serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids, with specificity for both natural and recombinant mouse CLPP. The detection range is 1.56-100ng/mL with a sensitivity of 0.78ng/mL. CLPP is a protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process, and it resides in the mitochondrion matrix.

CLPP is an essential mitochondrial protease that plays a critical role in maintaining mitochondrial protein quality control and regulating mitochondrial function. Dysregulation of CLPP has been implicated in metabolic disorders, neurodegenerative diseases, and cancer, making the kit a valuable tool for studying mitochondrial proteostasis and disease pathogenesis. Associated identifiers include UniProt O88696, NCBI Gene ID 53895, and a molecular weight of 29,800 Da.