Mouse Proprotein convertase subtilisin/kexin type 9 (Pcsk9) ELISA Kit

Assay Genie's Mouse Proprotein convertase subtilisin/kexin type 9 (PCSK9) ELISA Kit is a sandwich ELISA designed for the precise measurement of PCSK9 levels in mouse serum, plasma, and cell culture supernatants. The assay uses a colorimetric detection method and supports studies of cholesterol metabolism and cardiovascular biology, where PCSK9 is recognised as a key regulator of plasma cholesterol homeostasis and a research target linked to cardiovascular disease.

PCSK9 functions by binding low-density lipoprotein receptor family members, including the low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Dysregulation of PCSK9 has been associated with hypercholesterolemia autosomal dominant type 3 (HCHOLA3), a familial condition characterised by elevated circulating cholesterol contained in low-density lipoproteins alone or also in very-low-density lipoproteins.

The kit is reactive with mouse samples, with a reported standard range of 15.6-1000 pg/ml. The target protein corresponds to UniProt accession Q80W65, with a molecular weight of 74,823 Da and NCBI Gene ID 100102, and the product is intended for research use only.