Mouse Presenilin-2 (Psen2) ELISA Kit

Designed for the quantitative measurement of Presenilin-2 (Psen2) in mouse samples, this Sandwich ELISA kit from Assay Genie provides a tool for neuroscience and neurodegeneration research. Psen2 is described as a probable catalytic subunit of the gamma-secretase complex, an endoprotease that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein), and its dysregulation has been linked to disorders such as Alzheimer's disease.

The assay is reactive with mouse samples and has been validated for serum, plasma, tissue homogenates, cell culture supernatants, and other biological fluids. It detects natural and recombinant mouse Presenilin-2 with a detection range of 31.2–2000 pg/mL and a sensitivity of 15.66 pg/mL. Synonyms for the target include PS-2, Ad4h, Alg3, Ps-2, and Psnl2; the protein is a multi-pass membrane protein localised to the endoplasmic reticulum and Golgi apparatus membranes, with a molecular weight of 37,701 Da (UniProt Q61144). For research use only.