Mouse POU domain, class 3, transcription factor 4 (Pou3f4) ELISA Kit

A high-quality Sandwich ELISA Kit from Assay Genie designed for the precise measurement of POU3F4 levels in mouse serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. POU3F4 is a key transcription factor involved in the development of the inner ear and auditory system, with mutations in the POU3F4 gene associated with X-linked deafness, making it a valuable biomarker for studying hearing loss and related disorders.

The kit employs a colorimetric detection method and offers a detection range of 0.312-20ng/mL with a sensitivity of 0.159ng/mL. It is reactive with mouse samples and specific for natural and recombinant mouse POU domain, class 3, transcription factor 4, with the target protein localizing to the nucleus. Synonyms include Brain-specific homeobox/POU domain protein 4, Octamer-binding protein 9, Octamer-binding transcription factor 9, Brain-4, Oct-9, OTF-9, Brn-4, Brn4, and Otf9. The associated UniProt entry is P62515. Functionally, POU3F4 is a probable transcription factor that exerts its primary action widely during early neural development and in a very limited set of neurons in the mature brain, with defects in POU3F4 recognised as a cause of deafness X-linked type 2 (DFNX2).

This ELISA provides researchers with a reliable tool for investigating the role of POU3F4 in auditory development and exploring potential therapeutic interventions. For research use only. Recommended storage is at 4°C/-20°C, with long-term storage at -20°C.