Mouse Potassium Inwardly Rectifying Channel Subfamily J, Member 5 (KCNJ5) ELISA Kit

Quantitative measurement of potassium inwardly rectifying channel subfamily J member 5 (KCNJ5), also known as GIRK4 or Kir3.4, in mouse samples is supported by this ELISA Kit from Assay Genie. KCNJ5 is a G-protein-coupled inward rectifier potassium channel central to research on primary aldosteronism, where somatic mutations in the channel drive aldosterone-producing adenomas and secondary hypertension. The kit is widely used in studies of adrenal cortex biology, cardiovascular pathophysiology, and endocrine signaling, helping investigators explore how altered channel function contributes to disease phenotypes in murine models. Mouse tissue homogenates and other biological preparations are processed for quantification of channel expression, supporting investigations into channelopathies, atrial electrophysiology, and Gβγ-mediated signaling cascades. Reagents supplied in the kit enable 96 individual reactions on a microplate workflow, with all components validated specifically for mouse reactivity to reduce background and improve specificity. Each kit includes pre-coated plate wells, recombinant standards, detection reagents, wash buffers, and protocol documentation for research use only. Applications extend to pharmacology, endocrinology, nephrology, and molecular cardiology research, particularly where teams examine how KCNJ5 activity influences aldosterone output from the zona glomerulosa, vascular smooth muscle tone, or arrhythmia susceptibility in transgenic and knockout mouse strains.