Mouse Platelet Derived Growth Factor Receptor Like Protein (PDGFRL) ELISA Kit

PDGFRL, a transmembrane glycoprotein structurally related to PDGF receptors but lacking an active kinase domain, can be quantitatively measured in mouse research samples using the Assay Genie ELISA Kit. The protein serves as a distinctive marker for studies on extracellular signaling, tissue development, and tumor biology.

In cancer research, PDGFRL has attracted significant attention as a frequently silenced gene in colorectal tumors, where promoter methylation suppresses its expression. Mouse models are central to exploring how loss of PDGFRL influences stromal interactions, cell migration, and tumor microenvironment remodeling. Quantifying circulating or tissue-level PDGFRL protein supports mechanistic investigations into these pathways.

The kit is supplied as a complete microplate-based package containing all reagents needed to perform the assay, including the microplate, detection antibodies, standards, and buffer solutions. Researchers commonly combine ELISA results with Western blot, PCR, and immunohistochemistry workflows to validate PDGFRL expression changes across experimental conditions.

Standard laboratory practice involves refrigerated storage of unopened kits until first use. Researchers should aliquot reagents to limit freeze-thaw cycles and protect components from light to preserve antibody activity. The assay is intended for research use only and supports in vitro studies of PDGFRL function in mouse models of cancer, development, and stromal biology.