Mouse Phospholamban (PLN) ELISA Kit

Phospholamban (PLN) is a small transmembrane phosphoprotein that regulates cardiac calcium handling by inhibiting the sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) in its unphosphorylated state. Disrupted PLN phosphorylation and expression are linked to dilated cardiomyopathy, hypertrophic remodeling, and heart failure, so quantitative PLN measurement supports preclinical cardiovascular research.

The Assay Genie Mouse Phospholamban ELISA Kit is configured for 96 assays per kit and enables quantitative measurement of PLN in mouse-derived samples. Application areas include cardiac contractility studies, beta-adrenergic signaling research, characterization of transgenic and knockout mouse models of cardiomyopathy, and evaluation of candidate therapeutics targeting SERCA regulation.

Mouse cardiac tissue homogenates serve as the predominant input matrix, with blood-derived fractions and additional specimen types also accepted per the assay's validated sample panel. The assay is intended for research use only and fits into workflows investigating calcium cycling, membrane protein biochemistry, and post-translational regulatory mechanisms in the heart.