Mouse Osteoprotegerin (OPG) ELISA Kit

Quantitative measurement of mouse osteoprotegerin (OPG) in biological research samples is the focus of this ELISA kit from Assay Genie, a microplate-format immunoassay supporting 96 assays per kit. Osteoprotegerin is a soluble decoy receptor of the TNF receptor superfamily that binds RANKL and thereby regulates osteoclast formation and bone resorption, making circulating OPG levels a useful biomarker in bone metabolism, osteoporosis, arthritis, vascular calcification, and related preclinical mouse studies.

The assay uses a colorimetric read-out and accepts a broad range of mouse-derived sample matrices, including serum samples, plasma samples, tissue homogenates, cell lysates, and cell culture supernatants. The procedure follows a standard immunoassay workflow suited to in vitro research use only, allowing laboratories to profile endogenous OPG from multiple sample sources without separate protocol optimizations.

Typical applications include evaluating bone-remodeling pathways in knockout or transgenic mouse models, screening compounds for skeletal effects, and studying the RANKL/OPG/RANK axis in immunology, endocrinology, and metabolic disease research. Each kit ships with the reagents needed to generate a standard curve and run the full plate, supporting routine use in academic, pharmaceutical, and translational research laboratories.