Mouse  Npc1  (NPC intracellular cholesterol transporter 1) ELISA Kit (MOFI01365)

NPC intracellular cholesterol transporter 1 (Npc1) is a polytopic transmembrane glycoprotein localized to the late endosomal and lysosomal limiting membrane, where it functions as the principal conduit for unesterified cholesterol egress from the lysosomal lumen to the endoplasmic reticulum and plasma membrane. Biallelic loss-of-function mutations in NPC1 cause Niemann-Pick disease type C, a progressive neurovisceral lysosomal storage disorder marked by intracellular cholesterol and glycolipid accumulation, making Npc1 abundance a key readout in hepatic and macrophage lipid-handling studies, foam-cell biology, atherosclerosis modeling, and neurodegenerative disease research. The Mouse Npc1 ELISA Kit from Assay Genie is configured as a 96 Assays plate-based immunoassay targeting mouse-derived specimen types, producing an enzyme-mediated color change at the reaction endpoint that can be quantified with conventional benchtop microplate readers. The kit ships with all buffers, calibrated reference standards, and conjugate reagents required to complete the procedure, supporting quantitative comparison of Npc1 concentrations across experimental cohorts. Each kit is intended for research use only and is shipped refrigerated to preserve reagent activity through transit.