Mouse NAD-dependent deacetylase sirtuin-2 (Sirt2) ELISA Kit

From Assay Genie, this Sandwich ELISA kit is specifically designed for the accurate detection of NAD-dependent deacetylase sirtuin-2 (SIRT2) levels in mouse serum, plasma, cell culture supernatants, tissue homogenates, and other biological fluids. The assay detects both natural and recombinant mouse SIRT2 with a detection range of 0.156–10 ng/mL and a sensitivity of 0.078 ng/mL.

SIRT2 is a key NAD-dependent protein deacetylase involved in regulating cellular processes such as metabolism, aging, and stress response, whose dysregulation has been implicated in cancer, neurodegenerative disorders, and metabolic disorders. The kit's known synonyms are SIR2-like protein 2, mSIR2L2, and Sir2l2, and it supports epigenetics research.

SIRT2 deacetylates internal lysines on histone and non-histone proteins, including the 'Lys-40' residue of alpha-tubulin, and is involved in the control of mitotic exit in the cell cycle via its role in cytoskeleton regulation, interacting with HDAC6 as part of a larger cytoskeleton-deacetylating complex. The kit is intended for research use only.