Mouse N-acetylgalactosamine-6-sulfatase (Galns) ELISA Kit

Designed for the quantitative measurement of mouse N-acetylgalactosamine-6-sulfatase (Galns), this Sandwich ELISA kit from Assay Genie is intended for research applications studying GalNS activity in biological samples. GalNS is an enzyme involved in the breakdown of glycosaminoglycans (GAGs), which are essential components of the extracellular matrix, and dysregulation of its activity has been linked to various lysosomal storage disorders. Defects in GALNS are the cause of mucopolysaccharidosis type 4A (MPS4A), also known as Morquio A syndrome.

The kit is reactive with mouse samples and is validated for serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids. Specificity is reported for natural and recombinant mouse N-acetylgalactosamine-6-sulfatase. Listed synonyms for the target include Chondroitinsulfatase, Galactose-6-sulfate sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, Chondroitinase, and GalNAc6S sulfatase.

Quantitative performance figures quoted by the manufacturer include a detection range of 78-5000 pg/mL and a sensitivity of 39 pg/mL. The associated UniProt entry is Q571E4, and the protein has a reported molecular weight of 57,673 Da, localising to the lysosome as a homodimer. The kit is for research use only.