Mouse Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) ELISA Kit

MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase) is the agrin receptor at the postsynaptic membrane of the neuromuscular junction, essential for acetylcholine receptor clustering and proper synapse formation between motor neurons and skeletal muscle fibers. Mutations disrupting MUSK signaling underlie congenital myasthenic syndromes, and autoantibodies against MUSK are a recognized cause of seronegative myasthenia gravis, making accurate quantification of the receptor a key readout in neuromuscular and neuroimmunology research.

The Assay Genie Mouse MUSK immunoassay kit is configured for quantitative measurement of mouse MUSK in tissue homogenates and other research samples, using paired capture and detection antibodies. Each kit provides reagents sufficient for 96 individual determinations run on a standard microplate, with a colorimetric endpoint readable on a conventional plate reader. Reagents are supplied in single-use vials, the assay is intended strictly for in vitro research use, and components should be stored refrigerated between runs to preserve reagent activity. The kit supports studies of neuromuscular junction biology, motor neuron disease models, and antibody-mediated myasthenia gravis in mouse systems.